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Interestingly, the concentration of GSH in different tissues of adult mammals may vary from 1 to 10 mM [44]

G6PD is a typical cytoplasmic enzyme, although some G6PD activity is associated with peroxisomes in liver and kidney cells

In this scenario, the selectivity of covalent binding will be determined by the surface exposure and intrinsic reactivity of an amino acid, and the presentation of drug-peptide conjugates will be independent of peptide-HLA binding affinity

In reality, methylation depends on cellular energy, mitochondrial one-carbon metabolism, amino-acid handling, redox balance and the removal of homocysteine and adenosine

Neuron 2014